Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Synergistic effect of Carum copticum and Mentha piperita essential oils with ciprofloxacin, vancomycin, and gentamicin on Gram-negative and Gram-positive bacteria

Fri May 20 01:16:22 2022

(2017) Synergistic effect of Carum copticum and Mentha piperita essential oils with ciprofloxacin, vancomycin, and gentamicin on Gram-negative and Gram-positive bacteria. International Journal of Pharmaceutical Investigation. pp. 82-87. ISSN 2230-973X

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Abstract

Background: Infectious diseases have always been an important health issue in human communities. In the recent years, much research has been conducted on antimicrobial effects of nature-based compounds because of increased prevalence of antibiotic resistance. The present study was conducted to investigate synergistic effect of Carum copticum and Mentha piperita essential oils with ciprofloxacin, vancomycin, and gentamicin on Gram-negative and Gram-positive bacteria. Materials and Methods: In this experimental study, the synergistic effects of C. copticum and M. piperita essential oils with antibiotics on Staphylococcus aureus (ATCC 25923), Enterococcus faecalis (ATCC 29212), Escherichia coli (ATCC 8739), Pseudomonas aeruginosa (ATCC 9027), Staphylococcus epidermidis (ATCC 14990), and Listeria monocytogenes (ATCC 7644) were studied according to broth microdilution and the MIC and fractional inhibitory concentration (FIC) of these two essential oils determined. Results: C. copticum essential oil at 30 mu g/ml could inhibit S. aureus, and in combination with vancomycin, decreased MIC from 0.5 to 0.12 mu g/ml. Moreover, the FIC was derived 0.24 mu g/ml which represents a potent synergistic effect with vancomycin against S. aureus growth. C. copticum essential oil alone or combined with other antibiotics is effective in treating bacterial infections. Conclusions: In addition, C. copticum essential oil can strengthen the activities of certain antibiotics, which makes it possible to use this essential oil, especially in drug resistance or to lower dosage or toxicity of the drugs.

Item Type: Article
Creators:
CreatorsEmail
Talei, G. R.UNSPECIFIED
Mohammadi, M.UNSPECIFIED
Bahmani, M.UNSPECIFIED
Kopaei, M. R.UNSPECIFIED
Keywords: Antimicrobial effect essential oil pathogenic bacteria plant synergism antibacterial activity antimicrobial activity chemical-composition antibiotics Pharmacology & Pharmacy
Divisions:
Page Range: pp. 82-87
Journal or Publication Title: International Journal of Pharmaceutical Investigation
Journal Index: ISI
Volume: 7
Number: 2
Identification Number: https://doi.org/10.4103/jphi.JPHI₁₂₁₇
ISSN: 2230-973X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/324

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