Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Molecular Mechanisms of Salmonella Effector Proteins: A Comprehensive Review

Sat May 21 04:48:13 2022

(2020) Molecular Mechanisms of Salmonella Effector Proteins: A Comprehensive Review. Infection and Drug Resistance. pp. 11-26. ISSN 1178-6973

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Abstract

Salmonella can be categorized into many serotypes, which are specific to known hosts or broadhosts. It makes no difference which one of the serotypes would penetrate the gastrointestinal tract because they all face similar obstacles such as mucus and microbiome. However, following their penetration, some species remain in the gastrointestinal tract; yet, others spread to another organ like gallbladder. Salmonella is required to alter the immune response to sustain its intracellular life. Changing the host response requires particular effector proteins and vehicles to translocate them. To this end, a categorized gene called Salmonella pathogenicity island (SPI) was developed; genes like Salmonella pathogenicity island encode aggressive or modulating proteins. Initially, Salmonella needs to be attached and stabilized via adhesin factor, without which no further steps can be taken. In this review, an attempt has been made to elaborate on each factor attached to the host cell or to modulating and aggressive proteins that evade immune systems. This review includes four sections: (A) attachment factors or T3SS- independent entrance, (B) effector proteins or T3SS-dependent entrance, (c) regulation of invasive genes, and (D) regulation of immune responses.

Item Type: Article
Creators:
CreatorsEmail
Azimi, T.UNSPECIFIED
Zamirnasta, M.UNSPECIFIED
Sani, M. A.UNSPECIFIED
Mehdi, M.UNSPECIFIED
Dallal, S.UNSPECIFIED
Nasser, A.UNSPECIFIED
Keywords: Salmonella effector proteins immune response T3SS pathogenesis enterica serovar typhimurium iii secretion system pathogenicity island containing vacuoles dendritic cells serotype typhimurium escherichia-coli epithelial-cells rho gtpases o-antigen Infectious Diseases Pharmacology & Pharmacy
Divisions:
Page Range: pp. 11-26
Journal or Publication Title: Infection and Drug Resistance
Journal Index: ISI
Volume: 13
Identification Number: https://doi.org/10.2147/idr.S230604
ISSN: 1178-6973
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2670

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