Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Synthesis, characterization, and evaluation of cytotoxicity, antioxidant, antifungal, antibacterial, and cutaneous wound healing effects of copper nanoparticles using the aqueous extract of Strawberry fruit and L-Ascorbic acid

Mon May 23 15:33:35 2022

(2020) Synthesis, characterization, and evaluation of cytotoxicity, antioxidant, antifungal, antibacterial, and cutaneous wound healing effects of copper nanoparticles using the aqueous extract of Strawberry fruit and L-Ascorbic acid. Polyhedron. p. 12. ISSN 0277-5387

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Abstract

Fragaria ananassa, also known as "Strawberry" is a common species in Iran and widely used for its anti-inflammatory, anti-ulcer, astringent, anti-allergic, antibacterial, antifungal, and antidiarrheal activities and also in the treatment of skin wounds. The purpose of the study was chemical characterization and assessment of cytotoxicity, antioxidant, antifungal, antibacterial, and cutaneous wound healing properties of copper nanoparticles (CuNPs) using the aqueous extract of Strawberry fruit and L-Ascorbic acid as reducing and stabilizing agents. These nanoparticles were characterized by FT-IR, UV-visible spectroscopy, EDS, FE-SEM, and TEM analysis. TEM images exhibited a uniform spherical morphology and diameters of 10-30 nm for the biosynthesized nanoparticles. DPPH free radical scavenging test revealed similar antioxidant properties for Strawberry, CuNPs, and butylated hydroxytoluene. The Strawberry and synthesized CuNPs had great cell viability dose-dependently against HUVEC cell line. In the microbiological part of this study, CuNPs showed higher antibacterial and antifungal properties than all standard antibiotics (p <= 0.01). Also, CuNPs prevented the growth of all bacteria at 2-8 mg/mL concentrations and destroyed them at 2-16 mg/mL concentrations (p <= 0.01). In the case of antifungal property of CuNPs, they inhibited the growth of all fungi at 2-4 mg/mL concentrations and destroyed them at 2-8 mg/mL concentrations (p <= 0.01). In vivo design, the use of CuNPs ointment in the treatment groups substantially remarkably raised (p <= 0.01) the wound contracture, hydroxyl proline, hexosamine, hexuronic acid, fibrocyte, and fibrocytes/fibroblast rate and reduced (p <= 0.01) the wound area, total cells, neutrophil, macrophage, and lymphocyte compared to Strawberry, CuSO4, tetracycline, Eucerin basal, and untreated control groups. In conclusion, the results of chemical characterization confirm that the Strawberry fruit can be consumed to produce copper nanoparticles with a remarkable amount of remedial effects without any cytotoxicity against HUVECs. (C) 2020 Elsevier Ltd. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Hemmati, S.UNSPECIFIED
Ahmeda, A.UNSPECIFIED
Salehabadi, Y.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Zangeneh, M. M.UNSPECIFIED
Keywords: CuNPs Strawberry Antioxidant Cytotoxicity Antimicrobial Cutaneous wound healing magnetically recyclable nanocatalyst zinc-oxide nanoparticles cancer-cell-line silver nanoparticles palladium nanoparticles catalytic-reduction green synthesis hydrogen-peroxide ag nanoparticles skin wounds Chemistry Crystallography
Divisions:
Page Range: p. 12
Journal or Publication Title: Polyhedron
Journal Index: ISI
Volume: 180
Identification Number: https://doi.org/10.1016/j.poly.2020.114425
ISSN: 0277-5387
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2600

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