Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Staphylococcus aureus versus neutrophil: Scrutiny of ancient combat

Sat May 21 03:51:19 2022

(2019) Staphylococcus aureus versus neutrophil: Scrutiny of ancient combat. Microbial Pathogenesis. pp. 259-269. ISSN 0882-4010

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Abstract

Staphylococcus aureus (S.aureus) is a Gram-positive bacterium that causes many infections and diseases. This pathogen can cause many types of infections such as impetigo, toxic shock syndrome toxin (TSST1), pneumonia, endocarditis, and autoimmune diseases like lupus erythematosus and can infect other healthy individuals. In the pathogenic process, colonization is a main risk factor for invasive diseases. Various factors including the cell wall-associated factors and receptors of the epithelial cells facilitate adhesion and colonization of this pathogen. S. aureus has many enzymes, toxins, and strategies to evade from the immune system either by an enzyme that lyres cellular component or by hiding from the immune system via surface antigens like protein A and second immunoglobulin-binding protein (Sbi). The strategies of this bacterium can be divided into five groups: A: Inhibit neutrophil recruitment B: Inhibit phagocytosis C: Inhibit killing by ROS, D: Neutrophil killing, and E: Resistance to antimicrobial peptide. On the other hand, innate immune system via neutrophils, the most important polymorphonuclear leukocytes, fights against bacterial cells by neutrophil extracellular trap (NET). In this review, we try to explain the role of each factor in immune evasion.

Item Type: Article
Creators:
CreatorsEmail
Nasser, A.UNSPECIFIED
Moradi, M.UNSPECIFIED
Jazireian, P.UNSPECIFIED
Safari, H.UNSPECIFIED
Alizadeh-Sani, M.UNSPECIFIED
Pourmand, M. R.UNSPECIFIED
Azimi, T.UNSPECIFIED
Keywords: Staphylococcus aureus Neutrophil Bacterial infection Immune system T cells chemotaxis inhibitory protein panton-valentine leukocidin immune evasion antimicrobial peptides complement c5 capsular polysaccharide virulence determinants extracellular traps stress resistance structural basis Immunology Microbiology
Divisions:
Page Range: pp. 259-269
Journal or Publication Title: Microbial Pathogenesis
Journal Index: ISI
Volume: 131
Identification Number: https://doi.org/10.1016/j.micpath.2019.04.026
ISSN: 0882-4010
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2395

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