Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A NOVEL STRATEGY FOR CORRECTION OF LIPID PROFILES VIA MATRICARIA CHAMOMILLA L

Fri May 20 02:12:18 2022

(2017) A NOVEL STRATEGY FOR CORRECTION OF LIPID PROFILES VIA MATRICARIA CHAMOMILLA L. Indo American Journal of Pharmaceutical Sciences. pp. 3819-3824. ISSN 2349-7750

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Abstract

Statins which are most useful in reducing blood fat have a chemical combination and present various side effects. Identifying some plants with positive effects on reducing blood fat can be a great alternative to these chemical drugs. The current study has been carried out to compare the effects of hydroalcoholic extract of Matricaria chamomilla on the serum lipid profile in hypercholesterolemic rats. Twenty-five male Wistar Rats, ranging in weight from 150 to 180 grams, were assigned to five groups: the control group received an ordinary dietary regimen, the sham group was fed on a high cholesterol (2) dietary regimen, experimental groups 1, 2 and 3 were given an ordinary nutrition plus chamomilla extract and Lovastatin dosages equal to 0.55 mg/ml, 1.1 mg/ml and 10 mg/kg were also, respectively, administered. Blood samples were taken on the first and the last days of the study period. To determine the blood's lipid profile and the serum cholesterol concentration, LDL-c, HDL-c and TG were measured and the results obtained for the groups were compared. The data were analyzed in SPSS 16 software. The results of the current research paper indicated that the treatment with 1.1 mg/ml chamomile hydroalcoholic extract and 10 mg/kg lovastatin significantly reduced (P<0.001) the total serum cholesterol concentration, LDL-c and TG in experimental hypercholesterolemic groups 2 and 3 as compared to the Sham Group. Also, it was found causing a significant increase in serum HDL-c in experimental hypercholesterolemic groups 2 and 3 in contrast to the Sham Group (P<0.001 and P<0.05, respectively). The mean weight scores of the Sham group and experimental group 1 were demonstrative of a significant increase in respect to control group (P<0.001 and P<0.01, respectively). The present study showed that the use of chamomile extract in hypercholesterolemic rats can bring about clearly discernible hypocholesterolemic effects and cause considerable and desirable effects on the serum lipid profile.

Item Type: Article
Creators:
CreatorsEmail
Amraei, M.UNSPECIFIED
Abbasi, N.UNSPECIFIED
Shirzadpour, E.UNSPECIFIED
Mohamadpour, M.UNSPECIFIED
Mousavi, S. F.UNSPECIFIED
Shahmir, P.UNSPECIFIED
Keywords: Hypocholesterolemic Matricaria chamomilla Lipid profile Lovastatin atherosclerosis pathogenesis extract Pharmacology & Pharmacy
Divisions:
Page Range: pp. 3819-3824
Journal or Publication Title: Indo American Journal of Pharmaceutical Sciences
Journal Index: ISI
Volume: 4
Number: 11
Identification Number: https://doi.org/10.5281/zenodo.1039869
ISSN: 2349-7750
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/203

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