Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Stem cell- and gene-based therapies as potential candidates in Alzheimer's therapy

Sun May 29 13:21:34 2022

(2018) Stem cell- and gene-based therapies as potential candidates in Alzheimer's therapy. Journal of Cellular Biochemistry. pp. 8723-8736. ISSN 0730-2312

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Abstract

Alzheimer's disease (AD) isa progressive neurodegenerative disorder, which is associated with impairments of memory, thinking, language, and reasoning. Despite extensive research aiming at the treatment of AD, durable and complete remissions are rare. Hence, new therapeutic approaches are required. Among various therapeutic approaches, stem cells (ie, neural stem cells, mesenchymal stem cells, and embryonic stem cells) and delivery of protective genes such asencoding nerve growth factor, APOE, and glial cell-derived neurotrophic factor have generated promise in AD therapy. Here, we summarized a variety of effective therapeutic approaches (ie, stem cells, and genes) in AD therapy.

Item Type: Article
Creators:
CreatorsEmail
Hosseini, S. A.UNSPECIFIED
Mohammadi, R.UNSPECIFIED
Noruzi, S.UNSPECIFIED
Mohamadi, Y.UNSPECIFIED
Azizian, M.UNSPECIFIED
Mousavy, S. M.UNSPECIFIED
Ghasemi, F.UNSPECIFIED
Hesari, A.UNSPECIFIED
Sahebkar, A.UNSPECIFIED
Salarinia, R.UNSPECIFIED
Aghdam, A. M.UNSPECIFIED
Mirzaei, H.UNSPECIFIED
Keywords: Alzheimer's disease exosome gene therapy microRNA stem cell therapy marrow stromal cells spinal-cord-injury mouse model amyloid-beta adenoassociated virus transgenic model neuronal loss in-vitro improve cognition memory deficits Biochemistry & Molecular Biology Cell Biology
Divisions:
Page Range: pp. 8723-8736
Journal or Publication Title: Journal of Cellular Biochemistry
Journal Index: ISI
Volume: 119
Number: 11
Identification Number: https://doi.org/10.1002/jcb.27202
ISSN: 0730-2312
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/15

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