Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Low expression levels of peroxisome proliferator-activated receptor gamma (PPARγ) in gastric cancer and its relationship with tumor progression

Fri May 20 01:48:19 2022

(2017) Low expression levels of peroxisome proliferator-activated receptor gamma (PPARγ) in gastric cancer and its relationship with tumor progression. Journal of Isfahan Medical School. pp. 911-918. ISSN 10277595 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in hindering the progression and growth of cancer cells. The function of PPARγ in gastric cancer and its relationship with progression of the disease have not been appropriately defined. Therefore, this study examined the association of PPARγ expression in tumor with advancement of gastric cancer. Methods: In the cross-sectional case-control study, the expression of PPARγ in tumoral and the paired adjacent normal tissues of 50 patients with gastric cancer, who undergone tumor resection at Institute of Imam Khomeini University Hospital, Tehran, Iran, were assayed and compared using quantitative real-time polymerase chain reaction method. Correlation between PPARγ expression in tumor tissue and the cancer progression relevant clinicopathological features was evaluated using the Spearman’s rho correlation test. Findings: The relative expression levels of PPARγ in tumoral tissues were shown to be profoundly decreased compared with their adjacent normal tissues 0.36 (0.15-0.89) vs. 1.01 (0.83-1.16), P < 0.001. There was significant correlation between the relative expression level of PPARγ in tumoral tissues and clinicopathological features such as cancer staging, tumor differentiation, tumor size, and lymphatic and vascular invasion. However, there was no noticeable correlation between the relative PPARγ expression level and other features such as age, gender, and metastasis. Conclusion: Decreased expression of PPARγ in gastric cancer tissue compared to the adjacent normal tissues is inversely associated with the cancer progression and development relevant clinicopathological features; hence, it may play an important role in the pathophysiology of gastric cancer. © 2017, Isfahan University of Medical Sciences(IUMS). All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Basati, G.UNSPECIFIED
Mohammadpour, H.UNSPECIFIED
Emami-Razavi, A.UNSPECIFIED
Keywords: Cancer staging Disease progression Gastric cancer PPAR gamma peroxisome proliferator activated receptor gamma Article cancer surgery case control study clinical article cross-sectional study disease course human Iran lymph vessel metastasis peroxisome protein expression stomach cancer tumor differentiation tumor growth tumor volume
Divisions:
Page Range: pp. 911-918
Journal or Publication Title: Journal of Isfahan Medical School
Journal Index: Scopus
Volume: 35
Number: 440
ISSN: 10277595 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1285

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