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 مخزن اطلاعات پژوهشی و تحقیقاتی

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Signaling pathways of melatonin in prevention of liver disorders via suppressing of oxidative stress in cellular level

(2016) Signaling pathways of melatonin in prevention of liver disorders via suppressing of oxidative stress in cellular level. Biomedical and Pharmacology Journal.

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آدرس رسمی: https://www.scopus.com/inward/record.uri?eid=2-s2....

چکیده انگلیسی

Melatonin (MT) (N-acetyl-5-methoxytryptamine) is a lipophilic and hydrophilic indoleamine with various physiologic functions MT presents in all cells and tissues and distributes in all cell compartments. Liver is the only organ of circulating MT metabolism. The roles of MT in various liver pathologies have been extensively studied, and it is believed that oxidative stress (OS) and lipid peroxidation (LPO) are the key causing factors of almost all conditions compromising liver function, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), diabetes, liver fibrosis and cirrhosis. MT improves energy production and reduces apoptosis OS and LPO in liver. MT protects liver against OS through multiple ways: inhibition of inflammatory cytokines, direct scavenge of free radicals, stimulation of antioxidant enzymes, decrease of mitochondrial electron leakage and synergistic function with other classical antioxidants. © 2016, Oriental Scientific Publishing Company. All rights reserved.

نوع سند : مقاله
Additional Information: cited By 1
زبان سند: انگلیسی
کلید وازه ها (انگلیسی): Free radical; Liver disease; Melatonin; Reactive oxygen species
کاربر ارسال کننده: mahdi sharifi
URI: http://eprints.medilam.ac.ir/id/eprint/1946

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